Endocrine Abstracts

Osteoporosis is caused by a failure of bone homeostasis. The precise molecular mechanism controlling bone homeostasis is largely unknown. Increasing evidences that neurons and neurotransmitters are intimately involved in bone remodeling shed light on a novel regulatory mechanism for bone homeostasis. Namely, like all other homeostatic functions, bone remodeling is under the control of hypothalamus. We have uncovered that leptin, an adipocyte-derived anorexigenic hormone, regul...

Aims: We investigated the association between urinary pentosidine concentration (UPC) and vascular complications.Methods: UPC was measured in 66 patients (31 men and 35 women) with type 2 diabetes. We compared UPC between patients with and without diabetic microangiopathy, and between patients with and without macroangiopathy (cerebral infarction (CI), coronary artery disease, and peripheral arterial disease). Stepwise regression analysis was performed t...